Human Saga

Daily History Challenge · No. 100 · Tuesday 6 October 2026 · Chain

Puzzle No. 100: Chain

The anchor was The Columbian Exchange and the demographic collapse of Indigenous America (1493 CE). Every challenger is listed below with its year.

The anchor

From 1493 (16th century)The Columbian Exchange and the demographic collapse of Indigenous America

Following Columbus's voyages, sustained Atlantic contact set off the Columbian Exchange, a vast two-way transfer of crops, animals, peoples and pathogens between the Old and New Worlds. American staples such as maize, potatoes, cassava, tomatoes, chillies, cacao and tobacco spread across Europe, Africa and Asia, eventually fuelling population growth worldwide, while Europeans brought wheat, sugar, horses, cattle, pigs and other livestock to the Americas, transforming landscapes and Indigenous societies. The most devastating transfers were biological: Eurasian diseases including smallpox, measles, influenza and typhus, to which Indigenous Americans had no immunity, swept through the hemisphere in repeated epidemics. Across the sixteenth and seventeenth centuries roughly 90 percent of the pre-contact population is estimated to have perished, among the largest demographic catastrophes in recorded history; epidemics such as the cocoliztli outbreaks in Mexico killed millions. This collapse facilitated European conquest, drove the importation of enslaved Africans to replace lost labour, and permanently reshaped the world's diets, ecosystems and populations.

Read the full story · See the world in 1493 CE

The 10 challengers, in order of date

c. 509 BCE (traditional)Foundation of the Roman Republic

Before The Columbian Exchange and the demographic collapse of Indigenous America

Before The Columbian Exchange and the demographic collapse of Indigenous America

Before The Columbian Exchange and the demographic collapse of Indigenous America

26 January 1885Fall of Khartoum in the Mahdist War

After The Columbian Exchange and the demographic collapse of Indigenous America

1923Freud's The Ego and the Id Codifies the Psychoanalytic Model of Mind

After The Columbian Exchange and the demographic collapse of Indigenous America

After The Columbian Exchange and the demographic collapse of Indigenous America

1958Guinea Rejects France and Chooses Independence

After The Columbian Exchange and the demographic collapse of Indigenous America

After The Columbian Exchange and the demographic collapse of Indigenous America

After The Columbian Exchange and the demographic collapse of Indigenous America

After The Columbian Exchange and the demographic collapse of Indigenous America

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